Resources

March 28, 2024

Participant-first recruitment: Building relationships, trust, and seamless experiences

Evidation's clinical research experts sit down for a chat about overcoming barriers to both recruitment and enrollment.

From in-person trials to DCTs and back again: Why has implementation of remote trials been so challenging?

Evidation's Senior Director of Clinical Operations, Joyce Nortey, sheds light on some of the challenges and best practices for implementing decentralized clinical trials.

Quickly connect the right participants to your trial

Evidation can improve the speed of recruitment and the quality of potential trial participants by identifying, engaging with, and providing a point-of-trial entry for eligible members from within the Evidation Community. View the infographic for more information.

The voice of the patient: What participants really want (and don't want) from research programs

Supporting conversations at the point of care with personalized health insights

Read this case study to learn about how Evidation enables individuals to better understand and act on their heart health outside of clinical settings.

Using longitudinal RWD to boost activation along the patient journey

People now play a more active role in their own health—but too often don’t know about relevant care and resources.

Evidation enables rapid recruitment and enrollment for Veterans heart health program

Evidation, alongside key partners, will present findings from a Veterans heart health program at the American College of Cardiology's Annual Scientific Session & Expo.

American Life in Realtime: A benchmark registry of health data for equitable precision health

Ritika R. Chaturvedi, Marco Angrisani, Wendy M. Troxel, Tania Gutsche, Eva Ortega, Monika Jain, Adrien Boch & Arie Kapteyn

ALiR, funded by a grant from the NIH, is a first-of-its-kind, publicly available benchmark registry and research infrastructure for person-generated health data collected from smartphones and wearables, made possible by Evidation.

Evidation and Duke Big Ideas Lab partner to boost participation and increase equity in digital health research

Evidation and Duke Big Ideas Lab announce a partnership with the goal of increasing diversity and representation in digital health studies

Creating competitive advantage: Privacy and security by design in mHealth and digital health products

Alea Garbagnati, Esq. and Lauren Wu, Esq.

Evidation's Head of Privacy looks at the increased need for cybersecurity and privacy protection amidst the boom in digital health advancements.

American Bar Association

February 13, 2024

The case for multimodal data capture: Deeper insights and increased prediction accuracy

Evidation participated in an IEEE EMBS workshop that explored how machine learning can convert data into measures for both disease detection and overall quality of life. The key takeaways are presented in this article.

What possibly affects nighttime heart rate? Conclusions from n-of-1 observational data

Igor Matias, Eric J. Daza, Katarzyna Wac

Evidation's Lead Biostatistician, Eric J. Daza, worked with the Quality of Life Technology Lab to conduct an n-of-1 study using the MoTR method to evaluate the suggested effects of daily stressors on nighttime heart rate, sleep time, and physical activity in an individualized way.

Model-Twin Randomization (MoTR): A Monte Carlo method for estimating the within-individual average treatment effect using wearable sensors

Eric J. Daza, Logan Schneider

In this academic preprint, the model twin randomization (MoTR; "motor") method for analyzing possible causes and effects an individual's intensive longitudinal data is introduced.

Influence of digital intervention messaging on influenza vaccination rates among adults with cardiovascular disease in the United States: A decentralized randomized clinical trial

Nell J. Marshall, Jennifer L. Lee, Jessica Schroeder, Wei-Nchih Lee, Jermyn See, Mohammad Madjid, Mrudula R. Munagala, John D. Piette, Litjen Tan, Orly Vardeny, Michael Greenberg, Jan Liska, Monica Mercer, Sandrine Samson

Evidation research reveals that a personalized, evidence-based digital intervention could be effective in increasing vaccination rates in a population of high-risk people with cardiovascular disease.

Journal of Medical Internet Research

How can we optimise health technology assessment and reimbursement decisions to accelerate access to new cardiovascular medicines?

Martin R. Cowie, Biykem Bozkurt, Javed Butler, Andrew Briggs, Maria Kubin, Adrian Jonas, Amanda I. Adler, Bray Patrick-Lake, Faiez Zannad

This paper builds on discussions among clinical trialists, industry representatives, regulators, and patients, which took place at the 17th Global Cardiovascular Clinical Trialists (CVCT) Forum in December 2020.

International Journal of Cardiology

Using digital health technologies to transform community health and health equity

Evidation responded to an RFI from the White House Office of Science and Technology Policy (OSTP) to provide input on how digital health tools can transform community health and health equity.

Heart Health on Evidation

In collaboration with the American College of Cardiology (ACC), Evidation is conducting a nationwide initiative focusing on the lived experience of individuals with heart failure beyond the clinic walls.

Measuring health-related quality of life with multimodal data: Viewpoint

Ieuan Clay, Francesca Cormack, Szymon Fedor, Luca Foschini, Giovanni Gentile, Chris van Hoof, Priya Kumar, Florian Lipsmeier, Akane Sano, Benjamin Smarr, Benjamin Vandendriessche, Valeria De Luca

Evidation contributed to a summary of how multimodal technologies capable of measuring several modalities simultaneously provide value to stakeholders.

One third of Medicare and Medicaid beneficiaries face transportation insecurity that affects access to healthcare and essential medications

Evidation research reveals that beneficiaries missed doctors’ appointments or ran out of medicine because they could not access transportation.

Evidation Health, American College of Cardiology announce Achievement for Heart Health, a program to help individuals monitor and improve cardiovascular health

Evidation and the ACC announce a first-of-its-kind virtual heart health engagement experience.

Evidation, USC and Rand awarded NIH R01 Research Project grant to develop a representative digital health dataset and novel data science methods

Evidation, USC, and RAND announce a partnership to create a nationally representative digital health dataset, dubbed American Life in Real-time (ALiR).

Evidation partners with other industry leaders to launch resources to drive inclusion in digital health measurement

Evidation and other members of the Digital Health Measurement Collaborative Community (DATAcc) announced a new set of open-access resources to guide inclusivity in digital health measurement products from development to deployment.

Next generation patient engagement & enriched insights

Evidation has written a white paper that takes a closer look at the challenges of PGHD, its value to clinical decision makers, and how to contextualize it to optimize its value.

5 key factors to successfully leveraging person-generated health data

Evidation shares five key factors in leveraging person-generated health data (PGHD) to improve outcomes and care delivery.

Translating PGHD into measures that matter

Evidation provides key highlights from its "Translating PGHD into Measures that Matter" webinar.

Enabling individuals to act on heart health insights

Evidation brings together industry voices to address how to enable individuals to act on heart health insights.

Evidation + HealthVerity: The holistic patient journey: Fusing real-world data with person-generated health data

Evidation, Pfizer, and HealthVerity discuss how to fuse real-world data (RWD) with person-generated health data (PGHD).

Evolution or revolution: Translating PGHD into measures that matter

Evidation and industry leaders address how to translate patient-generated health data (PGHD) into meaningful measures in this webinar.

Johnson & Johnson launches Heartline™, the first-of-its-kind, virtual study designed to explore if a new iPhone app and Apple Watch can help reduce the risk of stroke

Evidation collaborates with Johnson & Johnson and Apple to create The Heartline Study, which aims to assess whether digital tools can reduce the likelihood of stroke and improve health outcomes.

AI: Leveraging wearables and other patient-generated data in research

Evidation co-founder and chief data scientist, Luca Foschini, discusses how patient-generated health data (PGHD) and artificial intelligence (AI) are advancing clinical studies for biotech and pharmaceutical companies.

Effect of different financial incentive structures on promoting physical activity among adults

Bachireddy C, Joung A, John LK, Gino F, Tuckfield B, Foschini L, Milkman KL

Evidation research reveals that financial incentives for physical activity are most effective when offered at a constant rate.

Deep learning models for electrocardiograms are susceptible to adversarial attack

Han X, Hu Y, Foschini L, Chinitz L, Jankelson L, Ranganath R

Evidation researchers develop a method to construct smoothed adversarial examples for ECG tracings that are invisible to human expert evaluation.

Machine intelligence in healthcare — Perspectives on trustworthiness, explainability, usability, and transparency

Cutillo CM, Sharma KR, Foschini L, Kundu S, Mackintosh M, Mandl, KD

Evidation research reveals that machine intelligence approaches have the potential to improve health through the facilitation of more efficient and effective provision of care.

The accuracy of self-reported blood pressure in the Medication Adherence Improvement Support App for Engagement–Blood Pressure (MedISAFE-BP) trial: Implications for pragmatic trials

Haff N, Lauffenburger JC, Morawski K, Ghazinouri R, Noor N, Kumar S, Juusola J, Choudhry NK

Evidation research reveals no patients could be identified for whom self-reported hypertension would be a reliable method for their inclusion in a pragmatic trial.

American Heart Journal

Remote digital monitoring for medical product development

Izmailova ES, Wagner JA, Ammour N, Amondikar N, Bell-Vlasov A, Berman S, Bloomfield D, Brady LS, Cai X, Calle RA, Campbell M, Cerreta F, Clay I, Foschini L, Furlong P, Goldel R, Goldsack JS, Groenen P, Folarin A, Heemskerk J, Honig P, Hotopf M, Kamphaus T, Karlin DR, Leptak C, Liu Q, Manji H, Mather RJ, Menetski JP, Narayan VA, Papadopoulos E, Patel B, Patrick-Lake B, Podichetty JT, Pratap A, Servais L, Stephenson D, Tenaerts P, Tromberg B, Usdin S, Vasudevan S, Zipunnikov V, Hoffmann SC

Evidation research concludes that digital monitoring data need to be integrated with the totality of the data in clinical trials to create a holistic picture of the health care of the future.

Clinical and Translational Science

Comparison of study samples recruited with virtual versus traditional recruitment methods

Heidi Moseson, Shefali Kumar, Jessie L. Juusola

Evidation research reveals that virtual recruitment may enhance efficiency and enable more individuals to participate in clinical research.

Contemporary Clinical Trials Communications

Development and application of a patient group engagement prioritization tool for use in medical product development

Perry B, Dombeck C, Smalley JB, Levitan B, Leventhal D, Patrick-Lake B, Brennan L, McKenna K, Hallinan Z, Corneli A

Evidation research reveals that engagement activities can enhance the quality and efficiency of clinical trials by improving patient recruitment and retention, reduce costs, and help trials meet expectations of regulators and payers.

Therapeutic Innovation & Regulatory Science

Digital measures that matter to patients: A framework to guide the selection and development of digital measures of health

Manta C, Patrick-Lake B, Goldsack J.C.

Evidation synthesizes and defines a sequential framework of core principles for selecting and developing measurements in research and clinical care that are meaningful for patients.

Reproducibility in machine learning for health research: Still a ways to go

McDermott M.B.A, Wang S, Marinsek N, Ranganath R, Foschini L, and Ghassemi M

Evidation research reveals that machine learning for health compared poorly to other areas regarding reproducibility metrics.

Science Translational Medicine

Evaluation, acceptance, and qualification of digital measures: From proof of concept to endpoint

Goldsack J.C, Dowling A.V, Samuelson D, Patrick-Lake B, and Clay I

Evidation research details the steps of bringing a successful proof of concept to scale, focusing on key decisions in the development of a new digital measure.

Karger Digital Biomarkers

Digital endpoints must meet patient needs

Technological advances are speeding the development of digital measures and endpoints throughout drug development and across therapeutic areas and patient populations. While regulators encourage stakeholders to pursue patient-centric approaches, few actionable guidances or standards exist.

It takes a village: Development of digital measures for computer scientists

Goldsack J.C and Clay I

Evidation research reveals a range of challenges and considerations where computer scientists can have a particular impact on the development of a new digital measure.

Sensor data integration: A new cross-industry collaboration to articulate value, define needs, and advance a framework for best practices

Clay I, Angelopoulos C, Bailey A.L., Blocker A, Carini S, Carvajal R, Drummond D, McManus K.F., Oakley-Girvan I, Patel K.B., Szepietowski P, and Goldsack J.C.

Evidation research reveals that to achieve real impact on patient lives, sensor data needs to be integrated and contextualized with many other data types.

Five-step action plan to implement your PGHD strategy: Leveraging person-generated health data (PGHD) to deliver actionable insights

Evidation has written a white paper that describes and expands on five key takeaways for organizations seeking to implement the use of person-generated health data (PGHD).

RWD-Cockpit: Application for quality assessment of real-world data

Babrak L, Smakaj E, Agac T, Asprion P, Grimberg F, Van der Werf D, van Ginkel E, Tosoni D, Clay I, Degan M, Brodbeck D, Natali E, Schkommodau E, MIho E

Evidation research reveals that multiple datasets can be preliminary evaluated regarding quality using the proposed metrics implemented in the RWD-Cockpit app.

National Library of Medicine

Advancing digital health applications: Priorities for innovation in real-world evidence generation

Stern A, Brönneke J, Debatin J, Hagen J, Matthies H, Patel S, Clay I, Eskofier B, Herr A, Hoeller K, Jakas A, Kramer D, Kyhlstedt M, Lofgren K, Mahendraratnam N, Muehlan H, Reif S, Riedermann L, Goldsack J

The Digital Medicine Society and the Health Innovation Hub of the German Federal Ministry of Health convened a set of roundtable discussions to bring together international experts in evidence generation for digital medicine products.

Science Direct - The Lancet Digital Health

Photograph of women who are part of ProjectTech watching video

February 13, 2024

A community takes action to help citizens improve their health by harnessing digital technology

Evidation collaborates with Project TECH, a faith-based organization in South Carolina, to create a co-learning environment designed to help eliminate barriers to using digital technologies.

Making equitable health a reality

Building an equitable and inclusive space in the healthcare ecosystem where everyone - research and health program participants, partners, and employees - can belong and feel valued is a foundational pillar of Evidation’s mission. National Minority Health Month provides an excellent opportunity for us to reflect on ways health and racial equity can be improved.

How do we make patient centricity a reality?

For years, the subject of fostering direct connections with patients has been highlighted by notable figures across the healthcare and life sciences industries as a key feature to be explored in future strategies.

COPD — Determine high-impact clinical markers with person-generated health data (PGHD)

Combining activity and behavioral-related data can predict exacerbations in Chronic Obstructive Pulmonary Disease (COPD) patients

Pilot results of a digital hypertension self-management program among adults with excess body weight: Single-arm nonrandomized trial

Folasade Wilson-Anumudu, Ryan Quan, Christian Cerrada , Jessie Juusola, Cynthia Castro, Carolyn Bradner Jasik, Michael Turken

Evidation research reveals that a digital hypertension self-management program can improve blood pressure and medication adherence.

A nationwide, patient-centric digital program to improve heart failure care: The Evidation - ACC Innovation Collaborative

Ernesto Ramirez, Marta Ferreira, Ieuan Clay, Sanjeev P. Bhavnani, Anusha Narayan

Evidation research reveals that a virtual program to engage Heart Failure patients in their health journey can yield novel insights and help improve care.

Journal of the American College of Cardiology

Press

February 13, 2024

Digital Medicine Society, Evidation, and industry partners launch toolkit to support reimbursement for new drugs developed using digital endpoints

Today, the Digital Medicine Society (DiMe), in partnership with Evidation, Anthem, Biogen, Eli Lilly, Janssen, Merck, Pfizer, and Savvy Co-op, announced the public launch of the 3Ps of Digital Endpoint Value (3Ps), a toolkit of resources created to facilitate the inclusion of digital endpoints as evidence for payers in reimbursement decisions for new drugs.

Evidation, VA collaborate to enroll Veterans in personalized heart health program

Evidation and the Department of Veterans Affairs and the Veterans Health Administration Innovation Ecosystem (VHAIE) announced today an initiative to enroll Veterans in Heart Health on Evidation—a specialized heart health program built on the Evidation app that encourages individuals to understand and engage with their cardiovascular health from anywhere, using their smartphones and wearable devices.

Evidation extends collaboration with Sanofi to develop and apply real-world evidence

Evidation announces its extension to collaborate with Sanofi in co-developing unique datasets to understand health in everyday life.

Dyslipidemia / High Cholesterol: PGHD delivers valuable insights for cholesterol management

Person-generated health data (PGHD) can lead to deeper understanding and help inform better treatment options.