Resources

Behavioral Engagement and Activation Model Study (BEAMS)

John D Piette, Keni C S Lee, Hayden B Bosworth, Diana Isaacs, Christian J Cerrada, Raghu Kainkaryam, Jan Liska, Felix Lee, Adee Kennedy, David Kerr

Evidation and Sanofi partnered to look at Type 2 Diabetes patients with and without digital health technology (DHT) use to understand who might require more tailored support to adopt DHTs.

Translational Behavioral Medicine

Participant-first recruitment: Building relationships, trust, and seamless experiences

Evidation's clinical research experts sit down for a chat about overcoming barriers to both recruitment and enrollment.

Patient and physician perspectives on the use of a connected ecosystem for diabetes management: International cross-sectional observational study

Elizabeth Benito-Garcia; Julio Vega; Eric J Daza; Wei-Nchih Lee; Adee Kennedy; Jean-Marc Chantelot

Evidation and Sanofi partnered to understand which type 2 diabetes patients are more likely to participate in and benefit from connected ecosystem programs.

JMIR Formative Research

From in-person trials to DCTs and back again: Why has implementation of remote trials been so challenging?

Evidation's Senior Director of Clinical Operations, Joyce Nortey, sheds light on some of the challenges and best practices for implementing decentralized clinical trials.

Quickly connect the right participants to your trial

Evidation can improve the speed of recruitment and the quality of potential trial participants by identifying, engaging with, and providing a point-of-trial entry for eligible members from within the Evidation Community. View the infographic for more information.

The voice of the patient: What participants really want (and don't want) from research programs

Increasing treatment rates with co-created patient engagement

Read this case study to learn how Evidation increased vaccination rates through customized messages and content.

Using longitudinal RWD to boost activation along the patient journey

People now play a more active role in their own health—but too often don’t know about relevant care and resources.

American Life in Realtime: A benchmark registry of health data for equitable precision health

Ritika R. Chaturvedi, Marco Angrisani, Wendy M. Troxel, Tania Gutsche, Eva Ortega, Monika Jain, Adrien Boch & Arie Kapteyn

ALiR, funded by a grant from the NIH, is a first-of-its-kind, publicly available benchmark registry and research infrastructure for person-generated health data collected from smartphones and wearables, made possible by Evidation.

Evidation and Duke Big Ideas Lab partner to boost participation and increase equity in digital health research

Evidation and Duke Big Ideas Lab announce a partnership with the goal of increasing diversity and representation in digital health studies

Creating competitive advantage: Privacy and security by design in mHealth and digital health products

Alea Garbagnati, Esq. and Lauren Wu, Esq.

Evidation's Head of Privacy looks at the increased need for cybersecurity and privacy protection amidst the boom in digital health advancements.

American Bar Association

Digital intervention increases influenza vaccination rates for people with diabetes in a decentralized randomized trial

J. L. Lee, L. Foschini, S. Kumar, J. Juusola, J. Liska, M. Mercer, C. Tai, R. Buzzetti, M. Clement, X. Cos, L. Ji, N. Kanumilli, D. Kerr, E. Montanya, D. Müller-Wieland, C. G. Ostenson, N. Skolnik, V. Woo, N. Burlet, M. Greenberg & S. I. Samson

Annual influenza vaccination is recommended for people with diabetes, but vaccination rates are suboptimal. This Evidation study aimed to increase influenza vaccination rate in people with self-reported diabetes.

The case for multimodal data capture: Deeper insights and increased prediction accuracy

Evidation participated in an IEEE EMBS workshop that explored how machine learning can convert data into measures for both disease detection and overall quality of life. The key takeaways are presented in this article.

Model-Twin Randomization (MoTR): A Monte Carlo method for estimating the within-individual average treatment effect using wearable sensors

Eric J. Daza, Logan Schneider

In this academic preprint, the model twin randomization (MoTR; "motor") method for analyzing possible causes and effects an individual's intensive longitudinal data is introduced.

Using digital health technologies to transform community health and health equity

Evidation responded to an RFI from the White House Office of Science and Technology Policy (OSTP) to provide input on how digital health tools can transform community health and health equity.

Measuring health-related quality of life with multimodal data: Viewpoint

Ieuan Clay, Francesca Cormack, Szymon Fedor, Luca Foschini, Giovanni Gentile, Chris van Hoof, Priya Kumar, Florian Lipsmeier, Akane Sano, Benjamin Smarr, Benjamin Vandendriessche, Valeria De Luca

Evidation contributed to a summary of how multimodal technologies capable of measuring several modalities simultaneously provide value to stakeholders.

One third of Medicare and Medicaid beneficiaries face transportation insecurity that affects access to healthcare and essential medications

Evidation research reveals that beneficiaries missed doctors’ appointments or ran out of medicine because they could not access transportation.

Evidation study validates key outcomes for Omada diabetes program

Evidation and Omada Health release the results of a clinical study on diabetes management program.

Evidation, USC and Rand awarded NIH R01 Research Project grant to develop a representative digital health dataset and novel data science methods

Evidation, USC, and RAND announce a partnership to create a nationally representative digital health dataset, dubbed American Life in Real-time (ALiR).

Evidation partners with other industry leaders to launch resources to drive inclusion in digital health measurement

Evidation and other members of the Digital Health Measurement Collaborative Community (DATAcc) announced a new set of open-access resources to guide inclusivity in digital health measurement products from development to deployment.

Next generation patient engagement & enriched insights

Evidation has written a white paper that takes a closer look at the challenges of PGHD, its value to clinical decision makers, and how to contextualize it to optimize its value.

Evidation study shows digital intervention increases flu vaccination rates among people with diabetes

Evidation's study, published in npj Digital Medicine, shows people with diabetes who received digital content via Evidation’s mobile app platform were more likely to get vaccinated.

5 key factors to successfully leveraging person-generated health data

Evidation shares five key factors in leveraging person-generated health data (PGHD) to improve outcomes and care delivery.

Translating PGHD into measures that matter

Evidation provides key highlights from its "Translating PGHD into Measures that Matter" webinar.

Evidation + HealthVerity: The holistic patient journey: Fusing real-world data with person-generated health data

Evidation, Pfizer, and HealthVerity discuss how to fuse real-world data (RWD) with person-generated health data (PGHD).

Evolution or revolution: Translating PGHD into measures that matter

Evidation and industry leaders address how to translate patient-generated health data (PGHD) into meaningful measures in this webinar.

AI: Leveraging wearables and other patient-generated data in research

Evidation co-founder and chief data scientist, Luca Foschini, discusses how patient-generated health data (PGHD) and artificial intelligence (AI) are advancing clinical studies for biotech and pharmaceutical companies.

Effect of different financial incentive structures on promoting physical activity among adults

Bachireddy C, Joung A, John LK, Gino F, Tuckfield B, Foschini L, Milkman KL

Evidation research reveals that financial incentives for physical activity are most effective when offered at a constant rate.

JAMA Network Open

Quantifying the impact of influenza among persons with type 2 diabetes mellitus: A new approach to determine medical and physical activity impact

Samson SI, Konty K, Lee WN, Quisel T, Foschini L, Kerr D, Liska J, Mills H, Hollingsworth R, Greenberg M, Beal AC

Evidation research reveals that influenza increases rates of pneumonia, heart disease, and abnormal glucose levels among people with type 2 diabetes mellitus.

Journal of Diabetes Science and Technology

Machine intelligence in healthcare — Perspectives on trustworthiness, explainability, usability, and transparency

Cutillo CM, Sharma KR, Foschini L, Kundu S, Mackintosh M, Mandl, KD

Evidation research reveals that machine intelligence approaches have the potential to improve health through the facilitation of more efficient and effective provision of care.

NPJ Digital Medicine

The accuracy of self-reported blood pressure in the Medication Adherence Improvement Support App for Engagement–Blood Pressure (MedISAFE-BP) trial: Implications for pragmatic trials

Haff N, Lauffenburger JC, Morawski K, Ghazinouri R, Noor N, Kumar S, Juusola J, Choudhry NK

Evidation research reveals no patients could be identified for whom self-reported hypertension would be a reliable method for their inclusion in a pragmatic trial.

American Heart Journal

Remote digital monitoring for medical product development

Izmailova ES, Wagner JA, Ammour N, Amondikar N, Bell-Vlasov A, Berman S, Bloomfield D, Brady LS, Cai X, Calle RA, Campbell M, Cerreta F, Clay I, Foschini L, Furlong P, Goldel R, Goldsack JS, Groenen P, Folarin A, Heemskerk J, Honig P, Hotopf M, Kamphaus T, Karlin DR, Leptak C, Liu Q, Manji H, Mather RJ, Menetski JP, Narayan VA, Papadopoulos E, Patel B, Patrick-Lake B, Podichetty JT, Pratap A, Servais L, Stephenson D, Tenaerts P, Tromberg B, Usdin S, Vasudevan S, Zipunnikov V, Hoffmann SC

Evidation research concludes that digital monitoring data need to be integrated with the totality of the data in clinical trials to create a holistic picture of the health care of the future.

Clinical and Translational Science

Comparison of study samples recruited with virtual versus traditional recruitment methods

Heidi Moseson, Shefali Kumar, Jessie L. Juusola

Evidation research reveals that virtual recruitment may enhance efficiency and enable more individuals to participate in clinical research.

Contemporary Clinical Trials Communications

Development and application of a patient group engagement prioritization tool for use in medical product development

Perry B, Dombeck C, Smalley JB, Levitan B, Leventhal D, Patrick-Lake B, Brennan L, McKenna K, Hallinan Z, Corneli A

Evidation research reveals that engagement activities can enhance the quality and efficiency of clinical trials by improving patient recruitment and retention, reduce costs, and help trials meet expectations of regulators and payers.

Therapeutic Innovation & Regulatory Science

Digital measures that matter to patients: A framework to guide the selection and development of digital measures of health

Manta C, Patrick-Lake B, Goldsack J.C.

Evidation synthesizes and defines a sequential framework of core principles for selecting and developing measurements in research and clinical care that are meaningful for patients.

Karger

Digital intervention is effective in increasing influenza vaccination in people living with diabetes

Foschini L, Lee J.L., Buzzetti R, Clement M, Cos X, Ji L, Kanumilli N, Kerr D, Martinez L, Montanya E, Müller-Wieland D, Östenson C.-G, Skolnik N, Woo V, Samson S

Evidation research reveals that leveraging new technology to deliver knowledge and information can improve influenza vaccination rates in high-risk populations.

European Association for the Study of Diabetes 2020

Early insights from a digitally enhanced diabetes self-management education and support program: Single-arm nonrandomized trial

Wilson-Anumudu F, Quan R, Sweet C.C., Cerrada C, Juusola J, Turken M, and Jasik C.B.

Evidation research provides early evidence that a digitally enhanced DSMES program improves HbA1c and disease self-management outcomes.

JMIR Publications

Reproducibility in machine learning for health research: Still a ways to go

McDermott M.B.A, Wang S, Marinsek N, Ranganath R, Foschini L, and Ghassemi M

Evidation research reveals that machine learning for health compared poorly to other areas regarding reproducibility metrics.

Science Translational Medicine

Evaluation, acceptance, and qualification of digital measures: From proof of concept to endpoint

Goldsack J.C, Dowling A.V, Samuelson D, Patrick-Lake B, and Clay I

Evidation research details the steps of bringing a successful proof of concept to scale, focusing on key decisions in the development of a new digital measure.

Karger Digital Biomarkers

Digital endpoints must meet patient needs

Technological advances are speeding the development of digital measures and endpoints throughout drug development and across therapeutic areas and patient populations. While regulators encourage stakeholders to pursue patient-centric approaches, few actionable guidances or standards exist.

It takes a village: Development of digital measures for computer scientists

Goldsack J.C and Clay I

Evidation research reveals a range of challenges and considerations where computer scientists can have a particular impact on the development of a new digital measure.

Digibiom 21

Sensor data integration: A new cross-industry collaboration to articulate value, define needs, and advance a framework for best practices

Clay I, Angelopoulos C, Bailey A.L., Blocker A, Carini S, Carvajal R, Drummond D, McManus K.F., Oakley-Girvan I, Patel K.B., Szepietowski P, and Goldsack J.C.

Evidation research reveals that to achieve real impact on patient lives, sensor data needs to be integrated and contextualized with many other data types.

Five-step action plan to implement your PGHD strategy: Leveraging person-generated health data (PGHD) to deliver actionable insights

Evidation has written a report that describes and expands on five key takeaways for organizations seeking to implement the use of person-generated health data (PGHD).

RWD-Cockpit: Application for quality assessment of real-world data

Babrak L, Smakaj E, Agac T, Asprion P, Grimberg F, Van der Werf D, van Ginkel E, Tosoni D, Clay I, Degan M, Brodbeck D, Natali E, Schkommodau E, MIho E

Evidation research reveals that multiple datasets can be preliminary evaluated regarding quality using the proposed metrics implemented in the RWD-Cockpit app.

National Library of Medicine

Advancing digital health applications: Priorities for innovation in real-world evidence generation

Stern A, Brönneke J, Debatin J, Hagen J, Matthies H, Patel S, Clay I, Eskofier B, Herr A, Hoeller K, Jakas A, Kramer D, Kyhlstedt M, Lofgren K, Mahendraratnam N, Muehlan H, Reif S, Riedermann L, Goldsack J

The Digital Medicine Society and the Health Innovation Hub of the German Federal Ministry of Health convened a set of roundtable discussions to bring together international experts in evidence generation for digital medicine products.

Science Direct - The Lancet Digital Health

Photograph of women who are part of ProjectTech watching video

A community takes action to help citizens improve their health by harnessing digital technology

Evidation collaborates with Project TECH, a faith-based organization in South Carolina, to create a co-learning environment designed to help eliminate barriers to using digital technologies.

Making equitable health a reality

Building an equitable and inclusive space in the healthcare ecosystem where everyone - research and health program participants, partners, and employees - can belong and feel valued is a foundational pillar of Evidation’s mission. National Minority Health Month provides an excellent opportunity for us to reflect on ways health and racial equity can be improved.

How do we make patient centricity a reality?

For years, the subject of fostering direct connections with patients has been highlighted by notable figures across the healthcare and life sciences industries as a key feature to be explored in future strategies.

Understanding the pandemic’s impact on the management of chronic conditions

The COVID-19 pandemic has deeply affected every part of our society and economy, and is likely to have a long-lasting impact for years to come. We sough to understand how it is affecting one of the most vulnerable segments of the population.

Pilot results of a digital hypertension self-management program among adults with excess body weight: Single-arm nonrandomized trial

Folasade Wilson-Anumudu, Ryan Quan, Christian Cerrada , Jessie Juusola, Cynthia Castro, Carolyn Bradner Jasik, Michael Turken

Evidation research reveals that a digital hypertension self-management program can improve blood pressure and medication adherence.

Digital Medicine Society, Evidation, and industry partners launch toolkit to support reimbursement for new drugs developed using digital endpoints

Today, the Digital Medicine Society (DiMe), in partnership with Evidation, Anthem, Biogen, Eli Lilly, Janssen, Merck, Pfizer, and Savvy Co-op, announced the public launch of the 3Ps of Digital Endpoint Value (3Ps), a toolkit of resources created to facilitate the inclusion of digital endpoints as evidence for payers in reimbursement decisions for new drugs.

Evidation extends collaboration with Sanofi to develop and apply real-world evidence

Evidation announces its extension to collaborate with Sanofi in co-developing unique datasets to understand health in everyday life.

Digital health interventions increase flu vaccinations in people with diabetes

Lee J, Foschini L, Samson S, Skolnik N, and Kerr D

Evidation research reveals that digital interventions have great potential for reducing health inequities, if the barriers surrounding Internet connectivity and access to devices can be reduced.