Thought Leadership

Participant-first recruitment: Building relationships, trust, and seamless experiences

Evidation's clinical research experts sit down for a chat about overcoming barriers to both recruitment and enrollment.

Thought Leadership

From in-person trials to DCTs and back again: Why has implementation of remote trials been so challenging?

Evidation's Senior Director of Clinical Operations, Joyce Nortey, sheds light on some of the challenges and best practices for implementing decentralized clinical trials.

Press

BARDA expands partnership with Evidation to validate and improve machine learning models for early detection of influenza-like illness using wearables

Evidation announced that BARDA has awarded the company a contract to fund the 2023 Influenza-like Illness (ILI) Detect & Protect Studies.

Case Studies

Quickly connect the right participants to your trial

Evidation can improve the speed of recruitment and the quality of potential trial participants by identifying, engaging with, and providing a point-of-trial entry for eligible members from within the Evidation Community. View the infographic for more information.

Thought Leadership

The voice of the patient: What participants really want (and don't want) from research programs

Case Studies

Increasing treatment rates with co-created patient engagement

Read this case study to learn how Evidation increased vaccination rates through customized messages and content.

Publications

Characterization of influenza-like Illness burden using commercial wearable sensor data and patient-reported outcomes: Mixed methods cohort study

Victoria Hunter, Allison Shapiro, Devika Chawla, Faye Drawnel, Ernesto Ramirez, Elizabeth Phillips, Sara Tadesse-Bell, Luca Foschini, Vincent Ukachukwu

Evidation research aimed to characterize the burden of influenza-like illness using commercial wearable sensor data and investigate the extent to which these data correlate with self-reported illness severity and duration.

Publications

Machine learning COVID-19 detection from wearables

Bret Nestor, Jaryd Hunter, Raghu Kainkaryam, Erik Drysdale, Jeffrey B Inglis, Allison Shapiro, Sujay Nagaraj, Marzyeh Ghassemi, Luca Foschini, Anna Goldenberg

Evidation research looks into which criteria must be met before a study can claim reasonable COVID-19 detection performance using data from wearable devices.

Thought Leadership

Using longitudinal RWD to boost activation along the patient journey

People now play a more active role in their own health—but too often don’t know about relevant care and resources.

Publications

American Life in Realtime: A benchmark registry of health data for equitable precision health

Ritika R. Chaturvedi, Marco Angrisani, Wendy M. Troxel, Tania Gutsche, Eva Ortega, Monika Jain, Adrien Boch & Arie Kapteyn

ALiR, funded by a grant from the NIH, is a first-of-its-kind, publicly available benchmark registry and research infrastructure for person-generated health data collected from smartphones and wearables, made possible by Evidation.

Publications

Predictors of seeking care for influenza-like illness in a novel digital study

Devika Chawla, Alejandra Benitez, Hao Xu, Victoria Whitehill, Sara Tadesse-Bell, Allison Shapiro, Ernesto Ramirez, Kelly Scherer, Luca Foschini, Faye Drawnel, Barry Clinch, Marco Prunotto, Vincent Ukachukwu

Evidation conducted a study that used person-generated health data (PGHD) to identify factors associated with seeking care for ILI.

Press

Evidation and Duke Big Ideas Lab partner to boost participation and increase equity in digital health research

Evidation and Duke Big Ideas Lab announce a partnership with the goal of increasing diversity and representation in digital health studies

Publications

Creating competitive advantage: Privacy and security by design in mHealth and digital health products

Alea Garbagnati, Esq. and Lauren Wu, Esq.

Evidation's Head of Privacy looks at the increased need for cybersecurity and privacy protection amidst the boom in digital health advancements.

Publications

COVID-19 real-world evidence primer

Amy Cavet; Claire Cravero, MPH; Aaron Galaznik, MD; Bray Patrick-Lake, MFS; Aniketh Talwai

Evidation contributed to this online resource consisting of seven chapters that cover types of RWD, methods in RWE generation, examples of RWE studies, and more.

Publications

Digital intervention increases influenza vaccination rates for people with diabetes in a decentralized randomized trial

J. L. Lee, L. Foschini, S. Kumar, J. Juusola, J. Liska, M. Mercer, C. Tai, R. Buzzetti, M. Clement, X. Cos, L. Ji, N. Kanumilli, D. Kerr, E. Montanya, D. Müller-Wieland, C. G. Ostenson, N. Skolnik, V. Woo, N. Burlet, M. Greenberg & S. I. Samson

Annual influenza vaccination is recommended for people with diabetes, but vaccination rates are suboptimal. This Evidation study aimed to increase influenza vaccination rate in people with self-reported diabetes.

Publications

Influenza surveillance using wearable mobile health devices

Konty, K. J., Bradshaw, B., Ramirez, E., Lee, W.-N., Signorini, A., & Foschini, L.

Evidation research reveals the potential of mHealth devices to register illness.

Press

Evidation launches FluSmart, a direct-to-person digital flu monitoring program, to better understand flu in everyday life

Evidation announces the launch of FluSmart, a direct-to-person digital flu monitoring program hosted on the Evidation platform.

Publications

Model-Twin Randomization (MoTR): A Monte Carlo method for estimating the within-individual average treatment effect using wearable sensors

Eric J. Daza, Logan Schneider

In this academic preprint, the model twin randomization (MoTR; "motor") method for analyzing possible causes and effects an individual's intensive longitudinal data is introduced.

Publications

Influence of digital intervention messaging on influenza vaccination rates among adults with cardiovascular disease in the United States: A decentralized randomized clinical trial

Nell J. Marshall, Jennifer L. Lee, Jessica Schroeder, Wei-Nchih Lee, Jermyn See, Mohammad Madjid, Mrudula R. Munagala, John D. Piette, Litjen Tan, Orly Vardeny, Michael Greenberg, Jan Liska, Monica Mercer, Sandrine Samson

Evidation research reveals that a personalized, evidence-based digital intervention could be effective in increasing vaccination rates in a population of high-risk people with cardiovascular disease.

Thought Leadership

Using digital health technologies to transform community health and health equity

Evidation responded to an RFI from the White House Office of Science and Technology Policy (OSTP) to provide input on how digital health tools can transform community health and health equity.

Publications

The burden of influenza on the US older population: A real-world health outcomes study

Evidation research reveals that health services usage, respiratory illnesses, and non-respiratory conditions among older adults increased in the period after influenza diagnosis.

Publications

Estimating the burden of influenza-like illness on daily activity at the population scale using commercial wearable sensors

Aziz Mezlini, Allison Shapiro, Eric J. Daza, Eamon Caddigan, Ernesto Ramirez, Tim Althoff, Luca Foschini

Evidation research reveals that most of the burden of influenza-like illness is invisible to health care and public health reporting systems.

Publications

Measuring health-related quality of life with multimodal data: Viewpoint

Ieuan Clay, Francesca Cormack, Szymon Fedor, Luca Foschini, Giovanni Gentile, Chris van Hoof, Priya Kumar, Florian Lipsmeier, Akane Sano, Benjamin Smarr, Benjamin Vandendriessche, Valeria De Luca

Evidation contributed to a summary of how multimodal technologies capable of measuring several modalities simultaneously provide value to stakeholders.

Press

One third of Medicare and Medicaid beneficiaries face transportation insecurity that affects access to healthcare and essential medications

Evidation research reveals that beneficiaries missed doctors’ appointments or ran out of medicine because they could not access transportation.

Press

NIH and Evidation Health enter Phase II of project to study early warning signs of COVID-19

Evidation and NIH announce they've entered Phase II of a study to identify early warning signs of COVID-19 using data from commercial wearable sensors.

Press

Evidation, USC and Rand awarded NIH R01 Research Project grant to develop a representative digital health dataset and novel data science methods

Evidation, USC, and RAND announce a partnership to create a nationally representative digital health dataset, dubbed American Life in Real-time (ALiR).

Press

Evidation Health and BARDA partner on early warning system for COVID-19

Evidation announces a new effort, funded by BARDA, to detect COVID-19 symptoms via an early warning algorithm.

Press

NYC Health and Evidation collaborate with the Icahn School of Medicine at Mount Sinai to launch study on COVID-19’s impact on mental health

Evidation and NYC Health announce a nationwide study that aims to understand the mental health impact of the COVID-19 pandemic.

Press

Evidation partners with other industry leaders to launch resources to drive inclusion in digital health measurement

Evidation and other members of the Digital Health Measurement Collaborative Community (DATAcc) announced a new set of open-access resources to guide inclusivity in digital health measurement products from development to deployment.

Thought Leadership

Next generation patient engagement & enriched insights

Evidation has written a white paper that takes a closer look at the challenges of PGHD, its value to clinical decision makers, and how to contextualize it to optimize its value.

Press

Evidation study shows digital intervention increases flu vaccination rates among people with diabetes

Evidation's study, published in npj Digital Medicine, shows people with diabetes who received digital content via Evidation’s mobile app platform were more likely to get vaccinated.

Thought Leadership

5 key factors to successfully leveraging person-generated health data

Evidation shares five key factors in leveraging person-generated health data (PGHD) to improve outcomes and care delivery.

Thought Leadership

Translating PGHD into measures that matter

Evidation provides key highlights from its "Translating PGHD into Measures that Matter" webinar.

Thought Leadership

Evaluating the accuracy of at-home rapid diagnostic test kits for influenza

Evidation shares findings on the accuracy of at-home influenza rapid diagnostic test kits.

Thought Leadership

Rapid identification of high-risk participants in a COVID-19 research study: How Evidation enables precision recruitment at scale

Evidation shares a recent method development paper published as a preprint on MedRxiv demonstrating precision recruitment in the context of COVID-19.

Thought Leadership

Evidation + HealthVerity: The holistic patient journey: Fusing real-world data with person-generated health data

Evidation, Pfizer, and HealthVerity discuss how to fuse real-world data (RWD) with person-generated health data (PGHD).

Thought Leadership

Evolution or revolution: Translating PGHD into measures that matter

Evidation and industry leaders address how to translate patient-generated health data (PGHD) into meaningful measures in this webinar.

Thought Leadership

AI: Leveraging wearables and other patient-generated data in research

Evidation co-founder and chief data scientist, Luca Foschini, discusses how patient-generated health data (PGHD) and artificial intelligence (AI) are advancing clinical studies for biotech and pharmaceutical companies.

Publications

Effect of different financial incentive structures on promoting physical activity among adults

Bachireddy C, Joung A, John LK, Gino F, Tuckfield B, Foschini L, Milkman KL

Evidation research reveals that financial incentives for physical activity are most effective when offered at a constant rate.

Publications

Quantifying the impact of influenza among persons with type 2 diabetes mellitus: A new approach to determine medical and physical activity impact

Samson SI, Konty K, Lee WN, Quisel T, Foschini L, Kerr D, Liska J, Mills H, Hollingsworth R, Greenberg M, Beal AC

Evidation research reveals that influenza increases rates of pneumonia, heart disease, and abnormal glucose levels among people with type 2 diabetes mellitus.

Publications

Large-scale influenza vaccination promotion on a mobile app platform: A randomized controlled trial

Lee WN, Stück D, Konti K, Rivers C, Brown CR, Zbikowski SM, Foschini L

Evidation research reveals that messages regarding influenza vaccinations were most effective the first time around; effectiveness decreased after each successive batch sent.

Publications

Machine intelligence in healthcare — Perspectives on trustworthiness, explainability, usability, and transparency

Cutillo CM, Sharma KR, Foschini L, Kundu S, Mackintosh M, Mandl, KD

Evidation research reveals that machine intelligence approaches have the potential to improve health through the facilitation of more efficient and effective provision of care.

Publications

Remote digital monitoring for medical product development

Izmailova ES, Wagner JA, Ammour N, Amondikar N, Bell-Vlasov A, Berman S, Bloomfield D, Brady LS, Cai X, Calle RA, Campbell M, Cerreta F, Clay I, Foschini L, Furlong P, Goldel R, Goldsack JS, Groenen P, Folarin A, Heemskerk J, Honig P, Hotopf M, Kamphaus T, Karlin DR, Leptak C, Liu Q, Manji H, Mather RJ, Menetski JP, Narayan VA, Papadopoulos E, Patel B, Patrick-Lake B, Podichetty JT, Pratap A, Servais L, Stephenson D, Tenaerts P, Tromberg B, Usdin S, Vasudevan S, Zipunnikov V, Hoffmann SC

Evidation research concludes that digital monitoring data need to be integrated with the totality of the data in clinical trials to create a holistic picture of the health care of the future.

Publications

Comparison of study samples recruited with virtual versus traditional recruitment methods

Heidi Moseson, Shefali Kumar, Jessie L. Juusola

Evidation research reveals that virtual recruitment may enhance efficiency and enable more individuals to participate in clinical research.

Publications

Development and application of a patient group engagement prioritization tool for use in medical product development

Perry B, Dombeck C, Smalley JB, Levitan B, Leventhal D, Patrick-Lake B, Brennan L, McKenna K, Hallinan Z, Corneli A

Evidation research reveals that engagement activities can enhance the quality and efficiency of clinical trials by improving patient recruitment and retention, reduce costs, and help trials meet expectations of regulators and payers.

Publications

Digital measures that matter to patients: A framework to guide the selection and development of digital measures of health

Manta C, Patrick-Lake B, Goldsack J.C.

Evidation synthesizes and defines a sequential framework of core principles for selecting and developing measurements in research and clinical care that are meaningful for patients.

Publications

Digital intervention is effective in increasing influenza vaccination in people living with diabetes

Foschini L, Lee J.L., Buzzetti R, Clement M, Cos X, Ji L, Kanumilli N, Kerr D, Martinez L, Montanya E, Müller-Wieland D, Östenson C.-G, Skolnik N, Woo V, Samson S

Evidation research reveals that leveraging new technology to deliver knowledge and information can improve influenza vaccination rates in high-risk populations.

Publications

Characterizing COVID-19 and influenza illnesses in the real world via person-generated health data

Shapiro A, Marinsek N, Clay I, Bradshaw B, Ramirez E, Min J, Trister A, Wang Y, Althoff A, and Foschini L

Evidation research reveals that COVID-19 symptoms tend to peak later and last longer than flu symptoms.

Publications

Reproducibility in machine learning for health research: Still a ways to go

McDermott M.B.A, Wang S, Marinsek N, Ranganath R, Foschini L, and Ghassemi M

Evidation research reveals that machine learning for health compared poorly to other areas regarding reproducibility metrics.

Publications

Evaluation, acceptance, and qualification of digital measures: From proof of concept to endpoint

Goldsack J.C, Dowling A.V, Samuelson D, Patrick-Lake B, and Clay I

Evidation research details the steps of bringing a successful proof of concept to scale, focusing on key decisions in the development of a new digital measure.

Publications

Dear watch, should I get a COVID-19 test? Designing deployable machine learning for wearables

Goldenberg A, Nestor B, Hunter J, Kainkaryam R, Drysdale E, Inglis J, Shapiro A, Nagaraj S, Ghassemi M, and Foschini L

Evidation research reveals that using a wearable device can reduce the burden of symptom surveys by 35%.

Thought Leadership

Digital endpoints must meet patient needs

Technological advances are speeding the development of digital measures and endpoints throughout drug development and across therapeutic areas and patient populations. While regulators encourage stakeholders to pursue patient-centric approaches, few actionable guidances or standards exist.

Publications

It takes a village: Development of digital measures for computer scientists

Goldsack J.C and Clay I

Evidation research reveals a range of challenges and considerations where computer scientists can have a particular impact on the development of a new digital measure.

Publications

An alternative to the ‘light touch’ digital health remote study: The stress and recovery in frontline COVID-19 healthcare workers study

Goodday M.S, Karlin E, Alfarano A, Brooks A, Chapman C, Desille R, Karlin D.R, Emami H, Woods N, Boch A, Foschini L, Wildman M, Cormack F, Taptiklis N, Pratap A, Ghassemi M, Goldenberg A, Nagaraj S, Walsh E, and Friend S

Evidation research found evidence for feasibility and acceptability of a participant-centric digital health study approach that involved building trust with participants and providing support through regular phone check-ins.

Publications

Sensor data integration: A new cross-industry collaboration to articulate value, define needs, and advance a framework for best practices

Clay I, Angelopoulos C, Bailey A.L., Blocker A, Carini S, Carvajal R, Drummond D, McManus K.F., Oakley-Girvan I, Patel K.B., Szepietowski P, and Goldsack J.C.

Evidation research reveals that to achieve real impact on patient lives, sensor data needs to be integrated and contextualized with many other data types.

Publications

Flu@home: The comparative accuracy of an at-home influenza rapid diagnostic test, using a pre-positioned test kit, mobile app, mail-in reference sample, and symptom-based testing trigger

Kotnik J, Cooper S, Smedinghoff S, Gade P, Scherer K, Maier M, Juusola J, Ramirez E, Naraghi-Arani P, Lyon V, Lutz B, Thompson M

Evidation research reveals that app-supported, pre-positioned at-home RDT kits using symptom-based triggers are effective in getting diagnostics into at-home settings.

Thought Leadership

Five-step action plan to implement your PGHD strategy: Leveraging person-generated health data (PGHD) to deliver actionable insights

Evidation has written a white paper that describes and expands on five key takeaways for organizations seeking to implement the use of person-generated health data (PGHD).

Publications

RWD-Cockpit: Application for quality assessment of real-world data

Babrak L, Smakaj E, Agac T, Asprion P, Grimberg F, Van der Werf D, van Ginkel E, Tosoni D, Clay I, Degan M, Brodbeck D, Natali E, Schkommodau E, MIho E

Evidation research reveals that multiple datasets can be preliminary evaluated regarding quality using the proposed metrics implemented in the RWD-Cockpit app.

Publications

Advancing digital health applications: Priorities for innovation in real-world evidence generation

Stern A, Brönneke J, Debatin J, Hagen J, Matthies H, Patel S, Clay I, Eskofier B, Herr A, Hoeller K, Jakas A, Kramer D, Kyhlstedt M, Lofgren K, Mahendraratnam N, Muehlan H, Reif S, Riedermann L, Goldsack J

The Digital Medicine Society and the Health Innovation Hub of the German Federal Ministry of Health convened a set of roundtable discussions to bring together international experts in evidence generation for digital medicine products.

Publications

Precision recruitment for high-risk participants in a COVID-19 cohort study

Mezlini A, Caddigan E, Shapiro A, Ramirez E, Kondow-McConaghy H, Yang J, DeMarco K, Naraghi-Arani P, Foschini L

Evidation describes an approach for reducing recruiting time and resources in a COVID-19 study by targeting recruitment to high-risk individuals.

Thought Leadership

A community takes action to help citizens improve their health by harnessing digital technology

Evidation collaborates with Project TECH, a faith-based organization in South Carolina, to create a co-learning environment designed to help eliminate barriers to using digital technologies.

Thought Leadership

Making equitable health a reality

Building an equitable and inclusive space in the healthcare ecosystem where everyone - research and health program participants, partners, and employees - can belong and feel valued is a foundational pillar of Evidation’s mission. National Minority Health Month provides an excellent opportunity for us to reflect on ways health and racial equity can be improved.

Thought Leadership

How do we make patient centricity a reality?

For years, the subject of fostering direct connections with patients has been highlighted by notable figures across the healthcare and life sciences industries as a key feature to be explored in future strategies.

Thought Leadership

Understanding the pandemic’s impact on the management of chronic conditions

The COVID-19 pandemic has deeply affected every part of our society and economy, and is likely to have a long-lasting impact for years to come. We sough to understand how it is affecting one of the most vulnerable segments of the population.

Thought Leadership

Rapid home tests are good, but digital health technology is even better at fighting COVID-19

Jennifer M. Radin, Giorgio Quer, Luca Foschini

Technology companies and device manufacturers should coordinate with public health officials to introduce a new era of precision public health.

Press

Digital Medicine Society, Evidation, and industry partners launch toolkit to support reimbursement for new drugs developed using digital endpoints

Today, the Digital Medicine Society (DiMe), in partnership with Evidation, Anthem, Biogen, Eli Lilly, Janssen, Merck, Pfizer, and Savvy Co-op, announced the public launch of the 3Ps of Digital Endpoint Value (3Ps), a toolkit of resources created to facilitate the inclusion of digital endpoints as evidence for payers in reimbursement decisions for new drugs.

Press

Evidation extends collaboration with Sanofi to develop and apply real-world evidence

Evidation announces its extension to collaborate with Sanofi in co-developing unique datasets to understand health in everyday life.

Publications

Digital health interventions increase flu vaccinations in people with diabetes

Lee J, Foschini L, Samson S, Skolnik N, and Kerr D

Evidation research reveals that digital interventions have great potential for reducing health inequities, if the barriers surrounding Internet connectivity and access to devices can be reduced.