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Is it safe to take a migraine cocktail?
Explore the medications in a migraine cocktail, what you need to consider before taking one, and safety precautions to keep in mind.

If you’ve ever had a migraine, you know how painful and disruptive it can be, making it difficult or even impossible to make it through your day. You might feel a throbbing headache, sensitivity to light and sound, nausea, and even dizziness. When over-the-counter pain relievers don’t help, many people look for something stronger—like a “migraine cocktail.” In this article, we’ll break down what’s in a migraine cocktail, when it’s used, and whether it’s the right option for you.
What is a migraine cocktail?
A migraine cocktail is a mix of medications used to treat a migraine attack. It's not a fancy drink — it’s just a nickname for combining drugs that work together to relieve migraine symptoms. Migraines are complicated, and sometimes, using multiple medications can help to target both causes and symptoms to help you find relief.
Migraine cocktails are often given in emergency rooms or urgent care clinics to people with severe, long-lasting, or treatment-resistant migraines. Sometimes, people create their own version at home using over-the-counter medications.
Migraine cocktails can work to:
- Stop the migraine pain
- Relieve nausea or vomiting
- Reduce inflammation
- Rehydrate the body
Depending on where you receive the treatment (hospital, clinic, or at home), the combination and dosage of your migraine cocktail can vary. Pro tip: if you find a migraine cocktail that works well for you, be sure to write down the medications and dosages, and carry it with you in your wallet or purse. If you get a migraine attack when you're out of town, this can help emergency room staff members provide the treatment you need without guessing what dosage of medications will work best for your unique treatment needs.
Are migraine cocktails safe?
Migraine cocktails can be very effective, but safety depends on a few things:
- Where you get the cocktail (ER vs. at home)
- The drugs included in the cocktail
- Your personal health history
- Other medications you’re taking
When given by a doctor or nurse in the emergency room, migraine cocktails are generally safe and closely monitored. Medical professionals check your vitals, watch for side effects, and adjust medications if needed. This is the safest way to receive a cocktail, especially if you’ve never had one before.
People sometimes try at-home versions using over-the-counter drugs like Excedrin or combinations of pain relievers and anti-nausea medicine. While this may work for some, mixing medications on your own can carry risks, especially if you:
- Take more than the recommended dose
- Mix drugs that shouldn’t be combined
- Have liver or kidney issues
- Are pregnant or nursing
- Take prescription medications
So, while migraine cocktails can be safe, it’s important to talk to your doctor first, especially if you're planning to mix medications at home.
Emergency room migraine cocktail components
Let’s look at what’s usually in a hospital-grade migraine cocktail. These medications work together to relieve migraine symptoms quickly and effectively.
Triptans
Triptans are prescription drugs designed to stop migraines once they’ve started. They work by narrowing blood vessels in the brain and blocking pain pathways.
Common triptans include:
- Sumatriptan (Imitrex)
- Rizatriptan (Maxalt)
- Zolmitriptan (Zomig)
Triptans are generally safe, but not for everyone. They can raise blood pressure and may not be suitable for people with heart disease, stroke risk, or certain circulation problems.
Antiemetics (Anti-Nausea Medications)
Migraines often come with nausea or vomiting. Antiemetics help control these symptoms. Some also reduce migraine pain and improve how well other drugs work.
Common antiemetics include:
- Metoclopramide (Reglan)
- Prochlorperazine (Compazine)
- Ondansetron (Zofran)
These drugs are usually safe, but they can cause side effects like drowsiness or restlessness. In rare cases, people may have muscle spasms or allergic reactions.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
NSAIDs help reduce pain and inflammation, and are identical or similar to drugs that you would purchase for pain relief over the counter at a drugstore.
NSAIDs commonly used in migraine cocktails include:
- Ketorolac (Toradol)
- Ibuprofen (Advil, Motrin)
- Naproxen (Aleve)
NSAIDs are effective, but using them too often or at high doses can cause stomach ulcers, kidney problems, and an increased risk of problematic bleeding. If you have a history of ulcers, bleeding issues, or kidney disease, your doctor might avoid using NSAIDs.
Magnesium
Magnesium sulfate is sometimes added to migraine cocktails, especially for people with menstrual migraines or migraines with aura. Magnesium is a mineral that helps relax blood vessels and reduce brain inflammation.
It’s usually given by IV and has very few side effects. Some people may feel flushed or warm during the infusion, but this goes away quickly. Magnesium is considered safe and well-tolerated by most people.
IV Fluids
Migraines can dehydrate you, especially if you’ve been vomiting. IV fluids help rehydrate the body and support better absorption of medications.
There are no risks to IV fluids for most people unless you have certain heart or kidney conditions that affect fluid balance. In those cases, your medical team will adjust the amount given.
Over-the-counter migraine cocktails
Not everyone goes to the ER for migraine relief. Some people use over-the-counter (OTC) drugs to make their own migraine cocktail at home. Excedrin Migraine is one of the most commonly used medications in OTC migraine cocktails.
What’s in Excedrin?
Excedrin Migraine contains:
- Aspirin (250 mg) – an NSAID that reduces pain and inflammation
- Acetaminophen (250 mg) – a pain reliever
- Caffeine (65 mg) – helps medications work faster and constricts blood vessels in the brain
This combo is FDA-approved for treating migraines and works well for many people when taken at the first sign of a migraine.
Is Excedrin Safe?
Yes, but only when used correctly.
Taking too much can lead to serious health problems, including:
- Liver damage (from too much acetaminophen)
- Stomach bleeding (from too much aspirin)
- Increased heart rate, anxiety, or insomnia (from too much caffeine)
To stay safe:
- Don’t take more than the label recommends
- Avoid mixing with other meds that contain aspirin, acetaminophen, or caffeine
- Don’t drink alcohol when using it
- Talk to your doctor if you’re on blood thinners, have liver issues, or are pregnant
Other OTC Options
Some people make their own cocktail using:
- Ibuprofen (Advil) or naproxen (Aleve)
- Acetaminophen (Tylenol)
- Caffeine pills or a strong cup of coffee
This can be helpful if you don't have Excedrin or can’t tolerate aspirin. Still, it’s best to ask a healthcare provider before trying this mix, especially if you’re unsure about dosing or safety.
Safety tips for taking a migraine cocktail
Whether you’re in the ER or at home, here are some general safety tips to keep in mind:
- Know your medications: Always check the labels of what you're taking. Many OTC and prescription drugs contain similar ingredients, especially acetaminophen or NSAIDs, and taking more than one product can easily lead to an overdose.
- Stick to the recommended dosage: Taking more won’t make the pain go away faster—it will only increase your risk of side effects or serious complications.
- Avoid frequent use: Migraine cocktails aren’t meant for daily use. Using them too often can lead to rebound headaches, also known as medication overuse headaches. This means the drugs can actually make your migraines worse over time.
- Talk to a doctor first: If you get frequent or severe migraines, you might need preventive treatment. A doctor can help create a safer, long-term plan. You might also need testing to rule out other medical problems.
- Watch for side effects: Even safe medications can cause problems in some people. Call a doctor or go to the ER if you notice trouble breathing, chest pain, severe dizziness, confusion, uncontrolled vomiting, or signs of an allergic reaction.
Download Evidation and start using MigraineSmart today
Migraines can make it tough to enjoy your day-to-day life. Understanding your triggers and tracking your symptoms can help you better understand the causes of your migraines, allowing you to lessen the frequency and severity of attacks. When you download the Evidation app, you'll be able to share the health-related data you're already tracking. We'll use this information to provide you with personalized insights that can help you better understand health issues, allowing you to take steps that can help you become your happiest, healthiest self.
You'll also gain access to our MigraineSmart tool, which will allow you to track symptoms and identify triggers, providing valuable information to both you and your healthcare provider that can help you manage migraines. Click here to learn more about Evidation and MigraineSmart and get started today.

How Evidation Members Rallied Together Through COVID Pulse Survey
Through this challenging time, we we've been inspired by our members who responded to many questions with great empathy and creativity as they have adapted to new routines
We’ve been continuing to monitor sentiment in the community around the coronavirus through an Evidation Survey called COVID Pulse. Since kicking off the survey on March 12th right after the coronavirus was declared a pandemic, we’ve been sending out a weekly survey to our members.
We wanted to quantify participation and interest and share some of the latest trends from our most recent surveys. After we released the first survey, we received over 120,000+ responses in five days from over 20,000 United States zip codes. The highest percentage of responses came from the age groups in the range of 30–39, followed by the 18–29 age range, and lastly, the 40–49 range. Though, we did see representation from members ages 18–80+! We’ve been pleasantly surprised by the number of members who have continued to check in week over week to share their sentiment surrounding coronavirus. In fact, 11% of survey respondents have completed all five COVID Pulse Surveys to date and 22%+ completed four out of five COVID Pulse Surveys.
Most recently, we saw that over 85% of respondents said that if social distancing and stay at home orders were lifted today, they would know what to do to reduce chances of contracting the coronavirus. We also saw that members would continue to take the necessary precautions even if social distancing guidelines and stay at home orders were lifted. Over 60% would continue to stay at home and maintain social distancing behaviors. Additionally, nearly 70% said they would continue to start to wear protective equipment (for example a face mask) in public settings. For those who responded in locations where shelter in place has been lifted, only ~25% of respondents said that they were attending small social events.
Through this challenging time, we were also inspired by our members who responded to many questions with great empathy and creativity as they have adapted to new routines. In fact, when asked about their concerns if they were to be diagnosed, 75% of respondents expressed concern over getting others sick in their worries. This fear was followed by 60% of respondents expressing their worry over the physical discomforts of getting sick. Regarding ways to minimize changes to physical and mental health, we’ve seen an uptick in individuals sharing the importance of maintaining whatever routines possible, avoiding or taking breaks from the news, and a continued connection through video chats with friends and family. In fact, maintaining connection through social media scored high for Evidation Members as a method to socialize with others. Both last week and this week, 70% of respondents said they used social media to socialize with other people.

Get Your Cooking Game On
We know that being stuck indoors can be tough, but hopefully getting creative in the kitchen continues to be a fun pastime for many.
As we continue to be home during the coronavirus, we wanted to share another collection of snack ideas that you can make at home. We know that being stuck indoors can be tough, but hopefully getting creative in the kitchen continues to be a fun pastime for many.
- Try your hand at making a sweet or savory dip at home! Check out this greek cucumber yogurt dip from the Today Show or this three ingredient Healthy Honey Mustard Dip from the blog Cupcakes and Kale Chips.
- Experiment with no-bake bars like this No Bake Chocolate Oat Bar from All Recipes.
- Make your own cup of Dalgona Coffee (the Coronavirus trend that’s bringing out everyone’s internal barista)
- Test out the dessert that’s on the rise — make this three ingredient crème brûlée.
- Bring Disneyland to your home with Disney’s official homemade churro recipe.
- In the absence of a trip to Benihana’s, learn how to make this chicken fried rice at home.
- Check out Wacky cake. It’s an old favorite that came from the Depression when there was less access to ingredients. This cake only takes a few, simple ingredients.
- Have some Nutella handy in your pantry? Make these DIY Nutella pops with two other ingredients and a popsicle stick.
- Eat breakfast like one of the royal family by trying out Prince Charles’ famous cheesy baked eggs
- If you’re feeling fancy, you can also give Queen Elizabeth’s drop scones a try.

Oura Ring + Evidation = Match Made in Heaven
We know a big part of your Evidation experience is connecting apps and wearables to your account. Did you know here are more than 15 apps you can connect to help you earn points faster?
We know a big part of your Evidation experience is connecting apps and wearables to your account. To date, there are 15+ apps that you can connect to Evidation to track different activities that you take. For a reminder of which apps are available and where you can connect these apps to your experience, check out the Connect Apps page here.

We’re pleased today to share that the Oura Ring is now available to connect to Evidation. To connect your OURA ring and app, please follow these directions below:
- Log into the Evidation app or website > middle tab (apps section)
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2. Connect > Oura > Log in to OURA account
Note: it may take a few minutes to sync. If the app shows ‘not yet synced’
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Please go back to the middle tab and click down to refresh the app. If all dates did not retroactively sync, we recommend to disconnect the app from Evidation and reconnect.
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Can a furry friend help you cope with COVID?
You may be wondering, can owning a dog help you live a bit healthier? It turns out that new dog owners in general are a promising sign of better health!
We know that the last few months have put everyone into a new funk. Work, lifestyles, and exercise are all uniquely different than they may have been back when 2020 started.
That’s why we decided to look at how Evidation Members were resting and perhaps coping with some of these changes. To better understand our community, we decided to look at members who logged fitbit data in 2019 and 2020 between January and April to see if the pandemic was causing people to change up their nap schedule (hopefully for the better). Total number of naps per user per day were counted and the average nap count per day was calculated across our Evidation population. See the figure below:
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It appears that members are indeed napping far more than they were in 2019, beginning at about the time shelter in place orders began (which was around March 15, 2020, see grey in graph). On average, after shelter in place began, Evidation Members napped 14.37% more compared to the previous year during this time period. That’s many more naps! And hopefully, people are using this time to rest and recuperate.
We know that being mindful of sleep is one way people can take care of their health. However, we also observed in the news that fostering dogs has been at an all time high. It has become so popular that there’s even a waitlist.
So, in addition to users napping far more compared to last year, we delved more into what other things users are doing differently during this uncertain time. We released a survey a few weeks ago asking our members about their dogs, what type of relationship they have with their pets, and their activity habits with their pets. We received over 35,000 responses!
The first thing we wanted to know about our members and their pets was whether they had recently fostered a dog. It turns out that many people have begun to foster dogs, likely due to the pandemic. In total, 1,500+ Achievers indicated that they fostered their dog in between February and April of this year. Compare that to only 450+ Achievers during that time period last year. It definitely appears that the pandemic is causing people to go out and lend a helping hand to a homeless dog.
Of the people who recently fostered a dog, 55% indicated that they are now working from home due to the coronavirus. 39% said that they are still going into work, and 5% indicated that they had worked at home prior to the pandemic. These newly remote workers appear to be helping keep these shelters empty.
You may be wondering, can owning a dog help you live a bit healthier? It turns out that new dog owners in general are a promising sign of better health! For those that got their dog in 2019 or 2020, we found that members walk on average about 350 steps more per day, comparing the 30 days prior to getting a dog with the 30 days post getting a dog. Even in pandemic times (though members are walking far less than their 2019 dog owner counterparts, by about 1000 steps per day for those that got their dogs in March and April), members with new dogs are getting a 200 step increase in steps pre vs post dog ownership! Of course, this is expected, and we’re happy to report that dogs can help you get more steps. This trend turned out to be especially true for the older folks in our population. The 50+ population increased their steps by about 500 steps on average, compared to the ~200 step increase for those who are less than 50. Take a look:
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Another interesting question we asked our members was whether or not they sleep with their pets and how often per week they sleep with their pets. While we didn’t see a necessary difference in sleep quality or total time when our members had their dog buddies snoozing with them, we did see many people report that they sleep next to their dogs. In fact, 73% of Evidation Members said they nap or sleep next to their dog, at least once per week. For members who said they nap or sleep next to their dog, over 19,000 reported to nap or sleep next to their dog at least 4 times a week! This may sound surprising for the folks who may not have furry pals, but many can attest that sleeping next to their dogs can be a comforting ritual.
The last thing we wanted to explore was whether we could learn anything about our members who had reported that having a dog had helped them manage with their health-condition (heart condition, limited mobility, etc). We found that 1000+ members agreed that having a dog helped. It seemed as though having a furry friend was very helpful for emotional support and well being. We did not find any concrete information around managing conditions, but were glad to hear that those who had self reported with many conditions (specifically anxiety, asthma, chronic pain, depression, diabetes, high cholesterol, hypertension and migraines) and who had a higher resting heart rate found having a pet to be supportive.

5 Ways to Live a Climate-Friendly Lifestyle While Sheltering In Place
5 tips to help you lead a more climate-friendly lifestyle all while safely sheltering in place!
This week, we celebrated Earth Day on April 22nd. While this year brought a fresh perspective on the day, we still found some great ideas on how to be involved even if some swaps to celebrations meant staying indoors.
We hope that these tips will help you lead a more climate-friendly lifestyle all while safely sheltering in place!
- NASA created all kinds of resources online to give Earth Day the proper 50th year celebration it deserved. Check out everything from satellite views of the planet to global archives of photos capturing hurricanes, wildfires, icebergs and more!
- Try planting something and create a little garden. For simple tips, read more in this USA Today Article.
- Experiment with a plant based meal. If you have a sweet tooth, check out these quick, easy swaps.
- Make a grocery list via any of these apps (AnyList, Mealime, Bring! to name a few) to more easily keep track of home food needs.
- Small actions can have a big impact! Switch to paperless bank statements where you can and make sure to unplug electronic devices and appliances when you aren’t using them around your home.

Give the Happiness Project Podcast a Listen
Check out The Happiness Lab podcast by Dr. Laurie Santos
Given how tumultuous a time it has been for all, we found this podcast with episodes that will lift your spirits. The Happiness Lab podcast is narrated by Dr. Laurie Santos who is a Yale professor who teaches a class called “Psychology and the Good Life.” Through various episodes, Dr. Santos references the latest, relevant scientific research and relates them to everyday experiences and some unusual moments.
In this specific series, she’s curated a variety of content related to coping with the coronavirus. We found a lot of the commentary relatable and useful.
The content specific to coronavirus includes the following:
- Beat Your Isolation Loneliness
- Coach Yourself Through a Crisis
- Rising to a Challenge
- Calm Can Be Contagious
- Help Others to Help Yourself
- Keep Your Relationship Happy
- Checking in with Susan David
Susan David is a Psychologist at Harvard Medical School who offers ways to manage fear and panic through healthy strategies that anyone can adopt. - Laurie’s Personal Tips

How Evidation Members Are Hacking Together Home Workouts
Exercise tips, routines, and links to favorite home workout videos from our Evidation Memebers
Though many people generally exercise at home, we know that there are many others who have had to recreate their regular exercise habits during this time of sheltering in place. We polled our Evidation community, and 70% of members who responded said they have been finding new ways to exercise or stay active during the coronavirus pandemic. We then asked our members to share some of their exercise tips, routines, and links to their favorite home workout videos and helpful stretches to inspire others.
Here are a few ways you can exercise at home:
- If you do not have a home gym set up or any weights, you can find ways to use household items to get a great exercise in.
- Similarly, instead of buying separate weights to create your own home gym, you can also purchase exercise video games for the whole family to join on the fun.
- Online videos and streaming sites like YouTube are common places that Achievers are getting exercise routines from. Here’s a list of fitness gyms and studios that are offering free classes.
- Fitness apps like Fitbit or MyFitnessPal also offer exercise tips for at home workouts and is also an easy way to keep track of your progress as well.
- Pinterest has been a popular site for inspiration and tips since Achievers are able to pin multiple resources to one place. Here’s an example of the many you can find.
- Zumba is an exercise-dance program that has been great to do in groups or by yourself. Here’s a resource to do Zumba at home.
- You can search social media platforms to find inspiring fitness instructors or live exercise sessions. Platforms like Facebook, Instagram, or Snapchat are easy places to start!
- Create your own workout routine or do the alphabet challenge by doing bodyweight exercises that spell out your name. You can start out with your name, your pet’s name, or anyone else in your household!
- If you’re looking for other ways to get your cardio in, you can try jump rope exercises. It’s a simple, but effective way to increase your heart rate and work out multiple areas.
- Another helpful exercise is stretching your muscles, it’s a great way to start or end your exercise session.
- For Achievers who may have limited mobility or who have chronic pain, these exercises and stretches are a great way to keep your body moving.
- If you’re looking for other ways to improve your flexibility or range of motion, yoga and pilates can be a fun way to stretch your muscles. It’s great for anyone at any difficulty level!
- Other exercises like barre offer a mixture of isometric holds to increase strength and also improve posture. Barre also requires little to no equipment!
- Whether you own a regular bike or a stationary bike, biking is one exercise that is easy on the joints and helps reduce stress. Here’s a few tips on how to make biking more fun.
- Practicing tai chi and breathing exercises offers many benefits for both your mental and physical health. You can stream videos to follow along and do them on your own once you learn the motion.

Take Two: Creative Coronavirus Meals
We've had so many great community submissions that we wanted to round up a few more to share in our second recipe digest.
Coronavirus has changed our usual cooking routine! We hope that turning to the kitchen to try a new recipe has helped create some calm during an otherwise crazy time. We had so many great community submissions last week that we wanted to round up a few more to share in our second recipe digest.
Chicken Centered Recipes:
- Chicken Bread Recipe
- Spicy Basil Thai Chicken
- Baked Lemon Garlic Chicken
- Chicken Salad
- One Pot Creamy Chicken Tortellini
Veggie Friendly Meals:
- Cauliflower Mac and Cheese
- Socca Pizza with Sun-dried Tomatoes and Pesto
- Easy Hummus
- Chickpea and Spinach Curry
- Paleo Sweet Potato Toast
- BBQ Jackfruit Sandwiches with Avocado Slaw
- Black Bean Sweet Potato Enchiladas
Baking Goodness:
- 3 Ingredient Flatbread
- 30 minute dinner rolls
- Banana Bread and an oatmeal banana bread variety (for an extra twist banana coffee cake!)
- Creamy 1 ingredient banana ice cream
- Chocolate Chip Oatmeal Breakfast Squares
- Chocolate Peanut Butter No Bakes
As a reminder, we’ve pinned all of these to our Creative Coronavirus Meals board on Pinterest.

The Impact of Coronavirus on Cooking
We're blown away by the number of recipes our members have shared with us, so we decided that to reveal a series of recipes over the next few weeks.
We recently polled our community to ask if they had become more creative with their meals since the coronavirus. We heard back and 55% of members who responded said yes. We then followed up to see what types of recipes and food hacks are keeping them happy and healthy during this time.
We were overwhelmed by the number of recipes shared, so we decided that we’ll reveal a series of recipes over the next few weeks. We’ll curate all of our top community picks on our Creative Coronavirus Meals Pinterest board.
For our first edition of crowdsourced favorites, check out these go-to easy bites and soothing soups.
Go-To Easy Bites:
- Deviled Eggs
- 15 Pantry Recipes for Emergency Preparedness
- Self-Quarantine Recipes from the New York Times
- 5 ingredients or less high protein smoothies! (+a green smoothie)
- Easy Overnight Oats
Soothing Soups:
Vegetarian:
- Rosemary Garlic White Bean Soup
- Mexican Lentil Soup
- Alison Roman’s Chickpea Stew
- Spicy Instant Pot Taco Soup
- Cabbage Soup
Non-Vegetarian:
- Thai Red Curry Noodle Soup
- Quick and Easy Chinese Noodle Soup
- Zuppa Toscana Soup
- Cabbage Roll Soup Recipe
- Buffalo Black Bean Chilli